Research Progress of β-catenin Post-Translational Modification and its Function
نویسندگان
چکیده
منابع مشابه
Allosteric post-translational modification codes.
Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites. Because different chemical types of PTMs elicit different structural alterations, the effects of combinatorial...
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Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle ...
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A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round search of mass spectrometry data with ultrawide precursor mass tolerance. A second-round search employing the supplemented database conducted wi...
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Oregon Health and Science University, Knight Cancer Institute, Portland, Oregon, USA. Oregon Health and Science University, Department of Neurology, Portland, Oregon, USA Oregon Health and Science University, Molecular and Medical Genetics, Portland, Oregon, USA. Howard Hughes Medical Institute. Northwest VA Cancer Research Center, VA Medical Center Portland, Portland, Oregon, USA. Contributed ...
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Hypomyelinating leukodystrophies represent a genetically heterogeneous but clinically overlapping group of heritable disorders. Current management approaches in the care of the patient with a hypomyelinating leukodystrophy include use of serial magnetic resonance imaging (MRI) to establish and monitor hypomyelination, molecular diagnostics to determine a specific etiology, and equally important...
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ژورنال
عنوان ژورنال: SCIENTIA SINICA Vitae
سال: 2015
ISSN: 1674-7232
DOI: 10.1360/n052015-00069